Ciliary neurotrophic factor is an endogenous pyrogen.
نویسندگان
چکیده
منابع مشابه
Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice.
Ciliary neurotrophic factor (CNTF) is an abundant cytosolic molecule in myelinating Schwann cells of adult rodents. In newborn animals in which CNTF is not yet expressed, exogenous CNTF that is locally administered very effectively protects motoneurons from degeneration by axotomy. To evaluate whether endogenous CNTF, released after nerve injury from the cytosol of Schwann cells, supports moton...
متن کاملEndogenous Pyrogen
Abs t rac t -The effect of aging on the ability of macrophages to produce endogenous pyrogen/interleukin-1 (EP/IL-I) was tested in 13 young adult (2-3 mo) and 13 aged (24-26 mo) Fischer rats using a febrile response assay. Peritoneal macrophages from aged rats produced EP/IL-1 as well as young adult rats. Decreased production of EP/IL-1 does not appear to explain the diminished febrile response...
متن کاملTumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1
Recombinant human tumor necrosis factor (rTNF alpha) injected intravenously into rabbits produces a rapid-onset, monophasic fever indistinguishable from the fever produced by rIL-1. On a weight basis (1 microgram/kg) rTNF alpha and rIL-1 produce the same amount of fever and induce comparable levels of PGE2 in rabbit hypothalamic cells in vitro; like IL-1, TNF fever is blocked by drugs that inhi...
متن کاملPurification and characterization of an endogenous pyrogen.
Many microbes and their products are capable of producing fever when injected intravenously in various laboratory animals. Recent studies, involving passive transfer of serum from febrile donor animals to normal recipients, have shown that most, if not all, these agents cause fever indirectly via liberation of a circulating pyrogen of endogenous origin.' To date, the source of endogenous pyroge...
متن کاملThe trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat
Objective(s): Occlusal trauma is one of the most common forms of oral biting dysfunction. Long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. Through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (CNTF) on injured masseter muscle. Materials and Methods: Male Wistar rats (n=36) were random...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1993
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.90.18.8614